At the Biosystems Engineering Lab, we focus on engineering microbial systems to produce biochemicals and bioremediate recalcitrant and toxic compounds. We put special effort into cellular reprogramming via genetic modifications. We also pursue to establish novel bioprocesses utilizing renewable carbon substrates from various waste streams. Besides, we attempt to systematically dissect the metabolic operation of microbes —single and communities—through metabolic network reconstruction, 13C-based flux analysis, and integration of omics data into genome-scale metabolic models. The isolation and characterization of novel microbial cell factories and bioremediators from extreme environments is also an intensive area of research in our group.